Interferons IFNs are proteins which are naturally produced by the immune system and possess a wide range of immune properties including antiviral activity, promotion of antigen presentation as well as inhibition of cell growth and proliferation. Interferons are therefore used in the treatment of hepatitis C, multiple sclerosis, some types of cancer, and autoimmune disorders. Human interferons are classified into three different groups according to the type of receptor to which they bind in order to signal.
Inflammatory breast cancer IBC is the most rare and aggressive subtype of breast cancer characterized by clusters of tumor cells invading lymph vessels, high rates of metastasis, and resistance to systemic chemotherapy. A major limitation to the development of more specific and effective treatments for IBC is a lack of identifiable molecular alterations that are specific to IBC. Emerging evidence suggests that the aggressive nature of IBC is not specific to IBC cells but instead driven by the interplay between autonomous signaling and context-dependent cytokine networks from the surrounding tumor microenvironment.
July 23, report. Medical Xpress -- Researchers working in Australia have found that certain breast cancer cells are able to switch off the gene that is responsible for causing the production of interferon, an immunity response protein that the body uses to fight off viral and bacterial infections. Because of this, the team writes in their paper published in Nature Medicinecancer cells are able to spread to other parts of the body, particularly bone, without being attacked by the immune system.
Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer. Bryan E. While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that target multiple aspects of the cancer-immunity cycle. Our own work involves the use of gene transfer technology to promote cell death and immune stimulation.
Clinical trials are research studies that involve people. The clinical trials on this list are studying Recombinant Interferon Alfa-2b. All trials on the list are supported by NCI.
Breast cancer is an extremely heterogeneous disease that affects close to two million women across the globe each year. Compelling clinical trial data have suggested that progestins have a role in breast cancer development, independent of the widely-studied estrogen receptor. The mechanism by which this occurs, however, is vastly understudied.
Oncotarget a primarily oncology-focused, peer-reviewed, open access, weekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.
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Skip to search form Skip to main content. Telli and James M. Triple-negative breast cancer TNBCthe deadliest form of this disease, lacks a targeted therapy.
Interferons are produced by the body's immune system. They attach to other immune system cells, activating them to help the body fight infections and cancer cells. Man-made versions of these substances are sometimes used for "immunotherapy" to boost the body's immune system to help it fight diseases, including cancer.